Alternatively folded proteins with unexpected beneficial functions
نویسندگان
چکیده
منابع مشابه
Alternatively folded proteins with unexpected beneficial functions.
HAMLET (human α-lactalbumin made lethal to tumour cells) and its related partially unfolded protein-fatty acid complexes are novel biomolecular nanoparticles that possess relatively selective cytotoxic activities towards tumour cells. One of the key characteristics is the requirement for the protein to be partially unfolded, hence endowing native proteins with additional functions in the altern...
متن کاملUnexpected and novel functions of complement proteins.
consists of three articles published by outstanding researchers in the field. The review by Alex Langford-Smith and his colleagues [8] presents a timely overview on the role of complement in macular degeneration. The article summarizes the recent findings on the role of complement factor H on eye inflammation which show that polymorphism in protein factor H has a significant impact on the devel...
متن کاملUnexpected and Novel Functions of Complement Proteins
consists of three articles published by outstanding researchers in the field. The review by Alex Langford-Smith and his colleagues [8] presents a timely overview on the role of complement in macular degeneration. The article summarizes the recent findings on the role of complement factor H on eye inflammation which show that polymorphism in protein factor H has a significant impact on the devel...
متن کاملTopological solitons and folded proteins.
We argue that protein loops can be described by topological domain-wall solitons that interpolate between ground states which are the α helices and β strands. We present an energy function that realizes loops as soliton solutions to its equation of motion, and apply these solitons to model a number of biologically active proteins including 1VII, 2RB8, and 3EBX (Protein Data Bank codes). In all ...
متن کاملGaussian Dynamics of Folded Proteins
Vibrational dynamics of folded proteins is studied using a Gaussian model in which the protein is viewed as a network, residues representing the junctions, and the connectivity being established by a single parameter harmonic potential. Application to seven proteins showed that the local packing density plays a major role in determining the vibrational spectrum at time scales of picoseconds. At...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biochemical Society Transactions
سال: 2012
ISSN: 0300-5127,1470-8752
DOI: 10.1042/bst20120029